Wednesday, May 28, 2025
7:30 am Check In & Morning Coffee
8:30 am Chair’s Opening Remarks
REVOLUTIONIZING OPHTHALMOLOGY THROUGH ARTIFICIAL INTELLIGENCE TO DETECT EARLIER VISION LOSS
9:00 am Panel Discussion: Delving into the Ethical, Economic & Legal Barriers to AI Algorithm Application in Ophthalmic Trials
Synopsis
- Addressing the complexity of sourcing and processing images from multiple providers while maintaining data integrity and compliance
- Navigating patient privacy and data security
- Exploring strategies to demonstrate the clinical validity of AI algorithms and secure Phase 3 trials and market approval
9:30 am Unearthing AI’s Impact on Clinical Retinal Studies to Elevate Outcomes From Recruitment to Results
Synopsis
- Detailing the protocol design of AI-derived photoreceptor layer abnormalities as an inclusion criterion
- Exploring AI-derived photoreceptor layer abnormalities as an endpoint
- Utilizing microperimetry to establish ovel functional endpoints
10:00 am Unmasking Bias and Embracing Uncertainty with AI to Accelerate Ophthalmology
Synopsis
- Discussing how biases impact diagnostic accuracy, particularly for underrepresented groups
- Presenting current or emerging methods to identify and reduce bias, such as reweighting datasets or algorithmic fairness interventions
- Proposing new ways to standardize datasets, external validations, or uncertainty metrics specific to ophthalmic AI
10:30 am Speed Networking
Synopsis
A prime chance to make the most of in-person networking with a niche community of ophthalmic professionals. Designed to maximize your introduction to numerous new individuals and serve as a catalyst for ongoing discussions during the summit.
11:00 am Morning Coffee Break
11:30 am Delving Into AI Screening for Clinical Trials
Synopsis
- AI pre-screening of imaging criteria for retinal diseases can potentially reduce screen failures.
- Automated imaging analysis streamlines patient stratification and trial enrollment, optimizing resource utilization.
- Scalable, cost-effective AI solutions enhance workflow efficiency and data consistency in clinical trials.
12:00 pm Session Reserved for iCare
12:30 pm Predicting Pancreatic Cancer Using AI Analysis of Fundus Images of the Retina of Diabetic Patients to Allow for Earlier Detection
Synopsis
- Exploring the potential presence of early signs of pancreatic cancer in the retina
- Using AI to analyze retinal vessels and identify distinct features in diabetic individuals who may later develop pancreatic cancer
- Developing an AI-based prediction model to forecast pancreatic cancer in diabetic patients by analyzing both retinal and pancreatic data which will eventually help detect cancer at early stages
1:00 pm Networking Lunch
INVESTIGATING THE LATEST ADVANCEMENTS WITH IMAGING BIOMARKERS TO SPEARHEAD DEVELOPMENT
2:00 pm Discussing the Technologies & Biomarkers Addressing Specific Disease States, with a Focus on Structural & Functional Biomarkers
Synopsis
- Summarizing the status of existing structural and functional endpoints in AMD
- Predicting GA growth and direction of growth
- Highlighting non-responders to therapy early in AMD treatment pathways
2:30 pm Roundtable: Exploring the State of Play with Biomarkers for AMD, GA & IRD
Synopsis
Join conversations with your fellow peers to discuss developments with structural and function biomarkers
for specific ophthalmic diseases
Moderator Feedback & Audience Debate
- Moderators will be assigned to each roundtable to facilitate discussion and collate the findings
- Following the roundtable discussions, they will present back to the entire delegation and open wider audience debate
AMD | GA | IRD
3:00 pm Utilizing Delayed Near InfraRed Analysis To Identify Novel Features of Non-Exudative AMD in a Natural History Study
Synopsis
- Interpreting cross-sectional and longitudinal multimodal images suggests that DNIRA provides a “functional footprint” of AMD
- Addressing the “roadmap” from imaging to biomarker development
- Considering the opportunities and challenges of integrating prospectively acquired, small datasets into AI-based biomarker development
3:30 pm Afternoon Break & Poster Session
Synopsis
Immerse yourself in an engaging and informal session, join your peers in a relaxed atmosphere that encourages meaningful conversions and relationship building. Explore a range of exciting poster presentations on the latest ophthalmic imaging biomarkers developments and utilize this opportunity to showcase your own innovations. To submit a poster for this session, please contact info@hansonwade.com.
PRECLINICAL DEVELOPMENTS TO ELEVATE TRANSLATIONAL CAPABILITIES TO PREVENT BLINDING DISEASES
4:00 pm Roundtable Discussion: Synergizing Molecular Imaging & Cross-Species Data to Achieve Alignment
Synopsis
A more practical and highly interactive breakout roundtable session where attendees can crowd-source solutions and share opinions on pre-assigned topic areas:
- Advanced molecular imaging techniques to enhance understanding in smaller models
- Standardizing data collection methods that align with clinical endpoints
- Discussing the potential of automating analysis techniques to draw parallels between models
Moderator feedback & audience debate
- Moderators will be assigned to each roundtable to facilitate discussion and collate the findings
- Following the roundtable discussions, they will present back to the entire delegation and open wider audience debate
4:30 pm Delving Into How Photopic Visual Function is Preserved in Retinal Remodeling
Synopsis
- Utilizing a multi-dimensional map of pathophysiology for the P23H mouse model to identifying novel stages of dysfunction and physiological biomarkers
- Overcoming dramatic and progressive photoreceptor loss with age, to achieve photopic measures of visual acuity and contrast sensitivity remained largely intact up to postnatal day (PND) 300
- Detailing how hyperactive neuronal activity emerges before aberrant glial and vascular changes, and before the dramatic decline of photopic spatial visual function